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This is the type of fat linked to increased risk of diabetes, heart disease, and other chronic conditions

The specific adverse events that researchers reported across multiple phase 2 and phase 3 trials involving hundreds of participants

Gutzwiller JP, Gke B, Drewe J, et al

10.1016/j.bone.2012.02.012 104 ScherJ

Subtle conformational dynamics allow the C-terminus of GLP-1 to access the ECD binding site, and the ligand binding triggers further dissociation of the ECD from the TMD allowing the N-terminus of GLP-1 to enter the orthosteric pocket in the TMD and activate the receptor